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Reserpine
The Industrial Laboratories Company, Inc. is pleased
to announce that method validation studies have been completed for the
detection, quantitation, and confirmation of reserpine in animal
plasma or blood using liquid chromatography tandem mass spectrometry
(LC-MSMS) with multiple reaction (MRM) mode.
Method LOD: 0.1 ng/mL in 0.5 mL plasma
Method LOQ: 0.1 ng/mL
For further information, please contact
Dr. Caroline
Wang or Petra Hartmann
Reserpine is an indole alkaloid that was first
isolated in 1952 from the dried root of Rauwolfia serpentina (Indian
snakeroot tree). It has been used in Western medicine as an
anti-psychotic and anti-hypertensive treatment. It has largely been
discontinued in human medicine due to side effects.
In horses, reserpine has found illicit use as a
sedative to quiet excitable or restless horses. The drug is unusual as
it takes many days for it to exert full effects and subtle sedation
may continue for many days after the last dose. Side effects in horses
include colic, gastrointestinal upset, and sweating over the back and
hind legs. Penile prolapse is present in male horses, and penile
paralysis is a possible complication. The drug is classified by the
Racing Commissioners International (RCI) as a Class 2 drug.
References:
1. http://www.wedgewoodpharmacy.com/monogtaphs/reserpine.asp
2. http://www.phytomedical.com/plant/reserpine.asp
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The Industrial Laboratories Company Inc